Transcript: Nlrp1b-002 OTTMUST00000084418.1

Description

NLR family, pyrin domain containing 1B

Location

Chromosome 11: 71,153,102-71,201,456 reverse strand.

About this transcript

This transcript has 14 exons and is annotated with 26 domains and features.

Gene

This transcript is a product of gene OTTMUSG00000006087 Show transcript tableHide transcript table

Name	Transcript ID	bp	Protein	Translation ID	Biotype	CCDS	UniProt
Nlrp1b-001	OTTMUST00000049394.1	4134	1174aa	OTTMUSP00000022877	<p>Genes and/or transcript that contains an open reading frame (ORF).</p>Protein coding	CCDS36210	-
Nlrp1b-002	OTTMUST00000084418.1	4131	1177aa	OTTMUSP00000045499	<p>Genes and/or transcript that contains an open reading frame (ORF).</p>Protein coding	CCDS48839	A1Z198
Nlrp1b-003	OTTMUST00000013757.4	4319	673aa	OTTMUSP00000043156	Transcript is thought to undergo nonsense mediated decay, a process which detects nonsense mutations and prevents the expression of truncated or erroneous proteins. Nonsense mediated decay	-	-

Summary

Statistics

Exons: 14 Transcript length: 4,131 bps Translation length: 1,177 residues

CCDS

This transcript is a member of the Mouse CCDS set: CCDS48839

Class

Known protein coding [Definition]

Author

This transcript was annotated by Havana

Version & date

Version 1, last modified on 17/06/2016 (Created on 15/09/2008)

Alternative symbols

RP23-478O10.2-002

Remarks

Highly polymorphic locus

NP_001155886.1

POLYMORPHISM: Nlrp1b gene is extremely polymorphic. 5 alleles have been described in 18 inbred strains: 1, 2, 3, 4 and 5. These alleles define susceptibility to Bacillus anthracis lethal toxin (LT). Alleles 2 (carried by A/J, C57BL/6J and I/LnJ), 3 (AKR/J, NOD/LtJ and SJL/J) or 4 (DBA/2J, P/J and SM/J) are not activated by LT. Alleles 1 (carried by 129S1/SvImJ, BALB/cJ, C3H/HeJ, CBA/J, FVB/NJ, NON/ShiLtJ, NZO (NZO/HlLtJ) and SWR/J strains) and 5 (CAST/EiJ) confer macrophage susceptibility to LT. In susceptible strains, infection by Bacillus anthracis leads to IL1B release, neutrophil recruitment and macrophage pyroptosis. This early inflammatory response confers increased resistance to infection (PubMed:16429160)

Other assemblies

This transcript maps to 71,153,102-71,201,456 in GRCm38 (Ensembl) coordinates.

Jump to this stable ID in Ensembl

Alternative transcripts

Ensembl transcript having exact match with Havana:	ENSMUST00000108515

Curation Method

Manual annotation from Havana

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Recent locations

Transcript: Nlrp1b-002 OTTMUST00000084418.1

Summary

Transcript-based displays