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MHC Class II region

The sequencing and annotation of the canine MHC class II region was part of a collaboration between the Genetics group at the Animal Health Trust and the HAVANA group at the Wellcome Trust Sanger Institute. The Centre for Integrated Genomic Medical Research at the University of Manchester and John Wagner at the Thomas Jefferson University also made significant contributions to the project.

Funding was provided by Dogs Trust (formerly the National Canine Defence League).

Relevant Publications:

  • Li R., Mignot E., Faraco J., Kadotani H., Cantanese J., Zhao B., Lin X., Hinton L., Ostrander E.A., Patterson D.F., de Jong P.J.
    Construction and Characterization of an Eightfold Redundant Dog Genomic Bacterial Artificial Chromosome Library
    Genomics (1999) 58, 9-17 [Pubmed]
  • Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A., Ollier W.E.R., Binns M.M.
    Genomic Sequence of the Class II Region of the Canine MHC: Comparison with the MHC of other Mammalian Species
    Genomics (2005) 85, 48-59 [Pubmed]